People who have had COVID-19 are more likely to develop chronic fatigue syndrome, officially known as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
That’s according to a study published in the Journal of General Internal Medicine earlier this month, which found that 4.5% of people infected with SARS-CoV-2, the virus that causes COVID, developed chronic fatigue.
In comparison, only 0.6% of study participants who did not have COVID developed the second condition.ALWAYS FEELING TIRED? EXPERTS SHARE 4 COMMON CAUSES OF DAYTIME FATIGUE
The researchers determined that cases of ME/CFS were 15 times higher than pre-pandemic levels.
People who have had COVID-19 are more likely to develop chronic fatigue syndrome, officially known as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). (iStock)
“As a researcher dedicated to understanding how viral infections lead to chronic illness, I suspected from the beginning of the pandemic that SARS-CoV2 could trigger ME/CFS, so these results are not surprising,” said lead study author Suzanne D. Vernon, PhD, from the Bateman Horne Center in Salt Lake City.
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The study was part of the National Institute of Health’s RECOVER (Researching COVID to Enhance Recovery) program, which aims to better understand, prevent and treat long COVID, according to an NIH press release.
The study included 11,785 participants. At least six months after they were infected with COVID, researchers assessed whether they had developed chronic fatigue. They then compared those results to 1,439 people who did not have COVID.

The researchers determined that cases of ME/CFS were 15 times higher than pre-pandemic levels. (iStock)
“There are no specific tests or biomarkers, so ME/CFS is diagnosed when someone has a constellation of specific symptoms,” Vernon told Fox News Digital.
“This study asked participants questions to determine what symptoms they were experiencing, which can be viewed as a limitation but is currently the approach used to diagnose ME/CFS.”
“It’s well-known that chronic fatigue syndrome can occur in the setting of viral infections.”
Dr. Kenneth J. Perry, a physician based in South Carolina, wasn’t surprised by the incidence of chronic fatigue after a SARS-CoV-2 infection.
“It’s well-known that chronic fatigue syndrome can occur in the setting of viral infections,” Perry, who was not involved in the research, told Fox News Digital.
“Given the fact that SARS-CoV-2 was a novel virus at the time of the pandemic, the incidence and prevalence of such post-infection syndromes was difficult to predict.”

“It’s well-known that chronic fatigue syndrome can occur in the setting of viral infections,” a physician told Fox News Digital. (iStock)
The study does have some limitations when attempting to compare between different viruses, the doctor noted.
“Patients were required to self-report their symptoms,” he said. “This makes the ability to compare symptoms across viruses difficult, as the spotlight on COVID will increase the possibility of selection bias.”
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It’s difficult to specifically determine how chronic fatigue happens in the setting of a viral infection, according to Perry.
“More studies would have to be done to determine the actual underlying pathophysiology of the disease,” he said. “Given that lack of complete understanding, it is difficult to determine how to adequately prevent the syndrome.”
What to know about chronic fatigue
ME/CFS is a “complex, serious and chronic condition that often occurs following an infection,” the NIH wrote.
The condition is marked by “new-onset fatigue” that lasts for at least six months and impairs the person’s ability to engage in ordinary activities.
“There are both physical and psychological components to the syndrome.”